• Corpus ID: 199523217

Kaempferol exerts antiproliferative effects on human ovarian cancer cells by inducing apoptosis , G 0 / G 1 cell cycle arrest and modulation of MEK / ERK and STAT 3 pathways

@inproceedings{Yang2019KaempferolEA,
  title={Kaempferol exerts antiproliferative effects on human ovarian cancer cells by inducing apoptosis , G 0 / G 1 cell cycle arrest and modulation of MEK / ERK and STAT 3 pathways},
  author={Shuli Yang and Lihui Si and Yan Jia and Wenwen Jian and Qing Yu and Min Wang and Ruixin Lin},
  year={2019}
}
Corresponding author: Ruixin Lin, MD. Department of General Surgery, the Second Hospital of Jilin University, no.218 Ziqiang street, Changchun, Jilin 130000, China. Tel & Fax: +86 0431 81136555, Email: RLakeshiattebe@yahoo.com Received: 12/09/2018; Accepted: 03/11/2018 Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways 
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Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis.

Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade.

Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid…

Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells

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Kaempferol inhibits cell proliferation by disrupting the cell cycle, which is strongly associated with the induction of arrest at G2/M phase and may induce apoptosis via p53 phosphorylation in human breast carcinoma MDA-MB-453 cells.

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The induction of cell cycle arrest may be one of the mechanisms by which kaempferol exerts anti-carcinogenic effects in colon cancer cells.

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Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G.

The objective of the present study was to investigate the effects of kaempferol, a flavonoid present in food, on the cytotoxicity of anticancer drugs and the mechanisms of drug resistance in the human glioblastoma cell line T98G.