Kaempferol Attenuates Cardiac Hypertrophy via Regulation of ASK1/MAPK Signaling Pathway and Oxidative Stress.

  title={Kaempferol Attenuates Cardiac Hypertrophy via Regulation of ASK1/MAPK Signaling Pathway and Oxidative Stress.},
  author={Hong Feng and Jianlei Cao and Guangyu Zhang and Yanggan Wang},
  journal={Planta medica},
  volume={83 10},
Kaempferol has been demonstrated to provide benefits for the treatment of atherosclerosis, coronary heart disease, hyperlipidemia, and diabetes through its antioxidant and anti-inflammatory properties. However, its role in cardiac hypertrophy remains to be elucidated. The aim of our study was to investigate the effects of kaempferol on cardiac hypertrophy and the underlying mechanism. Mice subjected to aorta banding were treated with or without kaempferol (100 mg/kg/d, p. o.) for 6 weeks… 

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Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

  • O. YamaguchiY. Higuchi K. Otsu
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
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