Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects.

  title={Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects.},
  author={Angel Josabad Alonso-Castro and Elizabeth Ortiz-S{\'a}nchez and Alejandro Garc{\'i}a-Regalado and Graciela Ru{\'i}z and Jos{\'e} Mart{\'i}n N{\'u}{\~n}ez-Mart{\'i}nez and Ignacio Gonz{\'a}lez-S{\'a}nchez and Valeria Quintanar-Jurado and Elizabeth Morales-S{\'a}nchez and Fabiola Dom{\'i}nguez and Gabriela L{\'o}pez-Toledo and Marco Cerb{\'o}n and Alejandro Garc{\'i}a-Carranc{\'a}},
  journal={Journal of ethnopharmacology},
  volume={145 2},
ETHNOPHARMACOLOGICAL RELEVANCE Justicia spicigera is used for the empirical treatment of cervical cancer in Mexico. Recently, we showed that Justicia spicigera extracts exerted cytotoxic and antitumoral effects and the major component of this extract was kaempferitrin (KM). MATERIALS AND METHODS The cytotoxic and apoptotic effect of KM on human cancer cells and human nontumorigenic cells were evaluated using MTT and TUNEL assays, and Annexin V/Propidium iodide detection by flow cytometry. The… CONTINUE READING


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