Kabat Database and its applications: future directions

  title={Kabat Database and its applications: future directions},
  author={George Johnson and Tai Te Wu},
  journal={Nucleic acids research},
  volume={29 1},
The Kabat Database was initially started in 1970 to determine the combining site of antibodies based on the available amino acid sequences. The precise delineation of complementarity determining regions (CDR) of both light and heavy chains provides the first example of how properly aligned sequences can be used to derive structural and functional information of biological macromolecules. This knowledge has subsequently been applied to the construction of artificial antibodies with prescribed… CONTINUE READING


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