KTX3, the kaliotoxin from Buthus occitanus tunetanus scorpion venom: one of an extensive family of peptidyl ligands of potassium channels.

@article{Meki2000KTX3TK,
  title={KTX3, the kaliotoxin from Buthus occitanus tunetanus scorpion venom: one of an extensive family of peptidyl ligands of potassium channels.},
  author={A Meki and P Mansuelle and Laraba-Djebari Fatima and Razika Oughideni and Herv{\'e} Rochat and Marie France Martin-Eauclaire},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2000},
  volume={38 1},
  pages={105-11}
}
A new ligand of the K+ channels sensitive to KTX was purified from the venom of Buthus occitanus tunetanus, using two steps of high-performance-liquid-chromatography and by following its ability to compete with [125I]-KTX for binding to the KTX receptor on rat brain synaptosomes. Amino-acid analysis, amino acid sequencing and mass spectroscopy defined this new ligand. KTX3, as a 37-amino acid peptide, with three disulfide bridges. Its sequence shares 76% identity with KTX. The main differences… CONTINUE READING