KSR, a novel protein kinase required for RAS signal transduction

@article{Therrien1995KSRAN,
  title={KSR, a novel protein kinase required for RAS signal transduction},
  author={Marc Therrien and Henry C. Chang and N M Solomon and Felix D. Karim and David A. Wassarman and Gerald M. Rubin},
  journal={Cell},
  year={1995},
  volume={83},
  pages={879-888}
}

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...

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KSR modulates signal propagation within the MAPK cascade.

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It is shown that murine KSR1 (mKSR1) cooperates with activated Ras to promote Xenopus oocyte maturation and cellular transformation and evidence that this cooperation occurs by accelerating mitogen and extracellular regulated kinase (MEK) and mitogen-activated protein Kinase (MAPK) activation.

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