KSR, a novel protein kinase required for RAS signal transduction

@article{Therrien1995KSRAN,
  title={KSR, a novel protein kinase required for RAS signal transduction},
  author={Marc Therrien and Henry C. Chang and N M Solomon and Felix D. Karim and David A Wassarman and Gerald M. Rubin},
  journal={Cell},
  year={1995},
  volume={83},
  pages={879-888}
}
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the beta subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that KSR functions in multiple receptor… CONTINUE READING

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