KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma

@article{Ma2015KSHVIA,
  title={KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma},
  author={Tao Ma and Harsh C Patel and Savalan Babapoor-Farrokhran and Renty B. Franklin and Gregg L Semenza and Akrit Sodhi and Silvia Montaner},
  journal={Angiogenesis},
  year={2015},
  volume={18},
  pages={477-488}
}
Kaposi’s sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR/HIF-1 is a fundamental pathway driving these processes through the upregulation of angiogenic and inflammatory proteins, including VEGF, ANGPTL4, and ANGPT2. Interestingly, HIF-1… CONTINUE READING
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Haines JL et al

  • V Venegas, J Wang, D Dimmock, In Wong LJ Real-time quantitative PCR analysis of mit content.
  • Current protocols in human genetics/editorial…
  • 2015
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