KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.

@article{Hwang2017KSHVencodedVI,
  title={KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.},
  author={Sung-Woo Hwang and DongIk Kim and Jae U Jung and Hye-Ra Lee},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={486 3},
  pages={700-705}
}
Before an infection can be completely established, the host immediately turns on the innate immune system through activating the interferon (IFN)-mediated antiviral pathway. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes a unique antagonistic mechanism of type I IFN-mediated host antiviral immunity by incorporating four viral interferon regulatory factors (vIRF1-4). Herein, we characterized novel immune evasion strategies of vIRF4 to inhibit the IRF7-mediated IFN-α production. KSHV… CONTINUE READING