KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation

Abstract

Kaposi's sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin structure inside latently infected cells with the majority of the viral genome having repressive marks. However, upon reactivation the viral chromatin landscape changes into 'open' chromatin through the involvement of lysine demethylases and methyltransferases. Besides… (More)
DOI: 10.1371/journal.ppat.1006482

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@inproceedings{Strahan2017KSHVEO, title={KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation}, author={Roxanne C Strahan and Maria McDowell-Sargent and Timsy Uppal and Pravinkumar Purushothaman and Subhash C Verma}, booktitle={PLoS pathogens}, year={2017} }