KSHV RTA Abolishes NFκB Responsive Gene Expression during Lytic Reactivation by Targeting vFLIP for Degradation via the Proteasome

@inproceedings{Ehrlich2014KSHVRA,
  title={KSHV RTA Abolishes NFκB Responsive Gene Expression during Lytic Reactivation by Targeting vFLIP for Degradation via the Proteasome},
  author={Elana S. Ehrlich and Jennifer C. Chmura and John C. Smith and Nene N. Kalu and Gary S. Hayward},
  booktitle={PloS one},
  year={2014}
}
Kaposi's sarcoma herpesvirus (KSHV) is a gamma-2 herpesvirus present in all cases of Kaposi's sarcoma, primary effusion lymphoma (PEL), and some cases of multicentric Castleman's disease. Viral FLICE inhibitory protein (vFLIP) is a latently expressed gene that has been shown to be essential for survival of latently infected PEL cells by activating the NFκB pathway. Inhibitors of either vFLIP expression or the NFĸB pathway result in enhanced lytic reactivation and apoptosis. We have observed a… CONTINUE READING

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Kaposi’s sarcomaassociated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency

Ye F-C, Zhou F-C, Xie J-P, T Kang, W Greene
J Virol • 2008
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