KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway

@article{Gao1997KSHVOK,
  title={KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway},
  author={Shou-Jiang Gao and Chris H. Boshoff and Sukhanya Jayachandra and Robin A Weiss and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang and Patrick S Moore},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={1979-1985}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus linked to the development of Kaposi's sarcoma and a rare B cell lymphoma, primary effusion lymphoma. The KSHV gene ORF K9 encodes vIRF which is a protein with low but significant homology to members of the interferon (IFN) regulatory factor (IRF) family responsible for regulating intracellular interferon signal transduction (Moore PS, Boshoff C, Weiss RA and Chang Y. (1996). Science, 274, 1739 – 1744). vIRF inhibits IFN… CONTINUE READING
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