KRAS mutation and immunohistochemical profile in intraductal papillary neoplasm of the intrahepatic bile ducts.

@article{Xian2017KRASMA,
  title={KRAS mutation and immunohistochemical profile in intraductal papillary neoplasm of the intrahepatic bile ducts.},
  author={Zhi-hong Xian and Chun Qin and Wen-Ming Cong},
  journal={Pathology, research and practice},
  year={2017},
  volume={214 1},
  pages={
          105-111
        }
}
Intraductal papillary neoplasm of bile duct (IPNB) is characterized by a spectrum of diseases ranging from low-grade intraepithelial neoplasia to invasive carcinoma. In the present study, we aimed to investigate immunophenotypic features and KRAS mutations in relation to pathological subtypes and grades in Chinese patients with IPNBs. A total of 46 patients with IPNBs and 11 invasive adenocarcinomas arising in IPNBs (invasive IPNBs) were enrolled and clinicopathological data were analyzed. It… CONTINUE READING

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