KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy

  title={KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy},
  author={E. Valtorta and Sandra Misale and A. Sartore-Bianchi and Iris D. Nagtegaal and F. Paraf and C. Lauricella and V. Dimartino and Sebastijan Hobor and B. Jacobs and C. Ercolani and S. Lamba and E. Scala and S. Veronese and P. Laurent-Puig and S. Siena and S. Tejpar and M. Mottolese and C. Punt and M. Gambacorta and A. Bardelli and F. Nicolantonio},
  journal={International Journal of Cancer},
KRAS mutations are the most common oncogenic event in colorectal cancer (CRC) progression and their occurrence is associated with lack of response to anti epidermal growth factor receptor (EGFR) targeted therapies. Using preclinical models and patients' samples we recently reported that the emergence of KRAS mutations but also KRAS amplification is associated with acquired resistance to the EGFR inhibitors cetuximab or panitumumab. We reasoned that KRAS amplification may also be responsible for… Expand
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