KRAS and DAXX/ATRX Gene Mutations Are Correlated with the Clinicopathological Features, Advanced Diseases, and Poor Prognosis in Chinese Patients with Pancreatic Neuroendocrine Tumors

@inproceedings{Yuan2014KRASAD,
  title={KRAS and DAXX/ATRX Gene Mutations Are Correlated with the Clinicopathological Features, Advanced Diseases, and Poor Prognosis in Chinese Patients with Pancreatic Neuroendocrine Tumors},
  author={Fei Yuan and Min Shi and Jun Ji and Hailong Shi and Chenfei Zhou and Yingyan Yu and Bing-Ya Liu and Zheng Gang Zhu and Jun Zhang},
  booktitle={International journal of biological sciences},
  year={2014}
}
BACKGROUND AND AIM Pancreatic neuroendocrine tumor (pNET) is a clinically rare and heterogeneous group of tumors; its pharmacogenetic characteristics are not fully understood. This study was designed to examine the relationship between key gene variations and disease development and prognosis among Chinese patients with pNET. METHODS Various pNET associated genes such as DAXX/ATRX, KRAS, MEN1, PTEN, TSC2, SMAD4/DPC, TP53 and VHL were analyzed in high-throughput sequencing. The links between… CONTINUE READING
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