KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

@article{Gaedcke2010KRASAB,
  title={KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.},
  author={Jochen Gaedcke and Marian Grade and Klaus Jung and Markus Schirmer and Peter Jo and Christoph Obermeyer and Hendrik Andreas Wolff and Markus Karl Alfred Herrmann and Tim Bei\ssbarth and Heinz Becker and Thomas Ried and Michael Ghadimi},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2010},
  volume={94 1},
  pages={76-81}
}
BACKGROUND AND PURPOSE KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established. MATERIALS AND METHODS DNA was isolated from pre-therapeutic biopsies of 94 patients who were treated within two phase-III clinical trials receiving preoperative chemoradiotherapy. Mutation status of KRAS exons 1-3 and BRAF exon 15 was… CONTINUE READING
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