KRAS Mutation and Microsatellite Instability: Two Genetic Markers of Early Tumor Development That Influence the Prognosis of Colorectal Cancer

@article{Nash2009KRASMA,
  title={KRAS Mutation and Microsatellite Instability: Two Genetic Markers of Early Tumor Development That Influence the Prognosis of Colorectal Cancer},
  author={Garrett M. Nash and Mark Gimbel and Alfred M. Cohen and Zhao-shi Zeng and Mackevin I. Ndubuisi and Daniel R. Nathanson and J{\"u}rg Ott and Francis Barany and Philip B. Paty},
  journal={Annals of Surgical Oncology},
  year={2009},
  volume={17},
  pages={416-424}
}
We examined two genetic markers established early in colorectal tumor development, microsatellite instability (MSI) and mutation of the KRAS proto-oncogene, to see if these genetic changes influence metastatic disease progression and survival. MSI and KRAS mutation status were assessed in 532 primary adenocarcinomas (stage I–IV) from patients treated by colon resection. Median follow-up was 4.1 years (range 0–13.3 years) overall, 5.4 years for survivors. MSI and KRAS mutation were detected in… CONTINUE READING

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