KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.

Abstract

BACKGROUND The treatment of metastatic colorectal cancer (mCRC) includes drugs targeting the epidermal growth factor receptor (EGFR). Mutation in codon 12 or 13 in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene, downstream of the EGFR, evokes constitutive activation of the RAS/RAF/MAPK signaling pathway and correlates with resistance to anti… (More)

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Cite this paper

@article{Kumar2014KRASGM, title={KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.}, author={Shalini Sree Kumar and Timothy Jay Price and Omar Mohyieldin and Matthew Borg and Amanda Rose Townsend and J E Hardingham}, journal={Gastrointestinal cancer research : GCR}, year={2014}, volume={7 1}, pages={23-6} }