KRABs RegulaTE Gene Expression beyond the Embryo.

Abstract

Transposable element (TE) silencing is initiated early in mammalian development and maintained during somatic differentiation. Reporting in this issue of Developmental Cell, Ecco et al. (2016) show that in somatic tissues, TE regulation, and its subsequent effect on host gene transcription, is dynamic rather than locked in a silent state. 
DOI: 10.1016/j.devcel.2016.03.006

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