KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

  title={KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions},
  author={Angelo Lupo and Elena Cesaro and Giorgia Montano and Diana Zurlo and Paola Izzo and Paola Costanzo},
  booktitle={Current genomics},
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest individual family of transcriptional repressors encoded by the genomes of higher organisms. KRAB domain, positioned at the NH2 terminus of the KRAB-ZFPs, interacts with a scaffold protein, KAP-1, which is able to recruit various transcriptional factors causing repression of genes to which KRAB ZFPs bind. The relevance of such repression is reflected in the large number of the KRAB zinc finger protein… CONTINUE READING
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