KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

@article{Montalban2010KR003048AP,
  title={KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.},
  author={Antonio Garrido Montalban and E. C. Boman and Chau-Dung Chang and Susana Conde Ceide and Russell Dahl and David Dalesandro and Nancy G. J. Delaet and Eric Erb and Justin T Ernst and Andrew Gibbs and Jeffrey S Kahl and Linda Kessler and Jan Lundstr{\"o}m and Stephen C Miller and Hiroshi Nakanishi and Edward Roberts and Eddine Saiah and Robert Sullivan and Zhijun Wang and Christopher J. Larson},
  journal={European journal of pharmacology},
  year={2010},
  volume={632 1-3},
  pages={93-102}
}
The tumor necrosis factor-alpha (TNF-alpha) cytokine, secreted by activated monocytes/macrophages and T lymphocytes, is implicated in several diseases, including rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory bowel disease, and osteoporosis. Monocyte/macrophage production of TNF-alpha is largely driven by p38alpha mitogen… CONTINUE READING