KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus.

  title={KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus.},
  author={Peizhou Liang and H Zhang and Guoxin Wang and Suping Li and Shujie Cong and Yingyun Luo and Biliang Zhang},
  volume={14 11},
NF-κB/p65 is retained in the cytoplasm until it is activated in response to stress. Nuclear import of p65 is regulated by importin α in a nuclear localization signal (NLS)-dependent manner. However, the role of importin β family members in the nuclear translocation of p65 is largely unclear. In this study, using high-content siRNA screening, we identified three of 17 importin β family members that are involved in the nuclear import of p65. Our data showed that knockdown of KPNB1, XPO7 and IPO8… CONTINUE READING
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This article is protected by copyright. All rights reserved. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin

  • KA Dean, O von Ahsen, D Gorlich, HM. Fried
  • Journal of cell science
  • 2001
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