KNa. A sodium-activated potassium current


Introduction Action potentials are the result of several ionic currents flowing through the cell membrane. In invertebrates such as the squid, action potentials are generated by only two currents (Hodgkin and Huxley 1952). In vertebrates however, many currents are involved during firing of nerve cells. In the quail ciliary or trigeminal neurones, for instance, it was found that there are at least five different currents acting together during a single action potential (Bader et al. 1984). They can be divided into two classes: the voltage dependent currents and those activated by intracellular messengers, such as the calcium-activated potassium current (Meech et al. 1975). The aim of this work is to describe a new type of potassium channel that is activated by a rise of the intracellular sodium concentration. This current was first described in heart muscle (Kameyama et al. 1984) and then in neurones (Bader et al. 1985; Hartung 1985). More recently, it was also observed in brainstem neurones (Dryer et al. 1988) and could be revealed using the single channel recording technique (Dryer et al. 1988; Bader et al. 1989)

DOI: 10.1007/BF00582252

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@article{Bertrand1989KNaAS, title={KNa. A sodium-activated potassium current}, author={Daniel Bertrand and Ch. Bader and L. Berheim and Claudia Haimann}, journal={Pfl{\"{u}gers Archiv}, year={1989}, volume={414}, pages={S76-S79} }