KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.

@article{Cheeseman2008KNL1AT,
  title={KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.},
  author={Iain M Cheeseman and Tetsuya Hori and Tatsuo Fukagawa and Arshad Desai},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 2},
  pages={
          587-94
        }
}
Chromosome segregation during mitosis requires the assembly of a large proteinaceous structure termed the kinetochore. In Caenorhabditis elegans, KNL-1 is required to target multiple outer kinetochore proteins. Here, we demonstrate that the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins. However, unlike in C. elegans, depletion of vertebrate KNL1 does not abolish kinetochore localization of the microtubule… CONTINUE READING