KNI‐577, a Potent Small‐Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition‐State Mimic

@article{Kiso1998KNI577AP,
  title={KNI‐577, a Potent Small‐Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition‐State Mimic},
  author={Y. Kiso and S. Yamaguchi and H. Matsumoto and T. Mimoto and R. Kato and S. Nojima and H. Takaku and T. Fukazawa and T. Kimura and K. Akaji},
  journal={Archiv der Pharmazie},
  year={1998},
  volume={331}
}
  • Y. Kiso, S. Yamaguchi, +7 authors K. Akaji
  • Published 1998
  • Chemistry, Medicine
  • Archiv der Pharmazie
  • The development of an effective therapeutic agent for the treatment of AIDS continues to be a challenging problem. Since the discovery that the virally encoded HIV protease is vital for propagation, inhibition of this enzyme has become a major target for AIDS chemotherapy. Consequently, numerous efforts aimed at the development of potent and selective inhibitors have been undertaken[2]. Based on the substrate transition state, we designed and synthesized a novel class of HIV protease inhibitors… CONTINUE READING
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