KNG1 Ile581Thr and susceptibility to venous thrombosis.

  title={KNG1 Ile581Thr and susceptibility to venous thrombosis.},
  author={Pierre-Emmanuel Morange and Tiphaine Oudot-Mellakh and W. Cohen and Marine Germain and No{\'e}mie Saut and Guillemette Antoni and M C Alessi and Marion Bertrand and A E Dupuy and L Letenneur and Mark Lathrop and Lorna M. Lopez and J Y Lambert and Joseph Emmerich and Philippe Amouyel and David A Tr{\'e}gou{\"e}t},
  volume={117 13},
Three single nucleotide polymorphisms (SNPs) were recently found to be associated with activated partial thromboplastin time (aPTT). Because shortened aPTT levels have been observed in patients experiencing venous thrombosis (VT), we investigated the effects of these 3 aPTT-associated SNPs, rs2731672, rs9898, and rs710446, on the risk of VT in a sample of 1110 healthy patients and 1542 patients with VT. Among the 3 tested SNPs, only rs710446 was associated with VT risk; the rs710446-C allele… CONTINUE READING
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