Corpus ID: 22204347

KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.

@article{Anderson1998KN93AI,
  title={KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.},
  author={M. E. Anderson and Andrew P Braun and Yuzhi Wu and Tong Lu and Howard Schulman and Ruey J. Sung},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 3},
  pages={
          996-1006
        }
}
The multifunctional Ca++/calmodulin-dependent protein kinase II (CaM kinase) mediates Ca++-induced augmentation of L-type Ca++ current (ICa); therefore it may act as a proarrhythmic signaling molecule during early afterdepolarizations (EADs) due to ICa. To investigate the hypothesis that ICa-dependent EADs are favored by CaM kinase activation EADs were induced with clofilium in isolated rabbit hearts. All EADs were rapidly terminated with ICa antagonists. Hearts were pretreated with the CaM… Expand
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TLDR
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TLDR
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