KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro.

@article{An2007KN93AS,
  title={KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro.},
  author={Ping An and Jun-Yong Zhu and Yan Yang and Peng Lv and Yi‐hao Tian and Ming-Kai Chen and He-sheng Luo},
  journal={World journal of gastroenterology},
  year={2007},
  volume={13 9},
  pages={1445-8}
}
AIM To investigate the effects of KN-93, a CaMKII selective inhibitor on cell proliferation and the expression of p53 or p21 protein in human hepatic stellate cells. METHODS Human hepatic stellate cells (LX-2) were incubated with various concentrations (0-50 micromol/L) of KN-93 or its inactive derivative, KN-92. Cell proliferation was measured by CCK-8 assay, and the expression of two cell cycle regulators, p53 and p21, was determined by SDS-PAGE and Western blotting. RESULTS KN-93 (5-50… CONTINUE READING