KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

  title={KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation},
  author={Changcun Guo and Lee H. Chen and Yafen Huang and Chun-Chi Chang and Ping Wang and Christopher J. Pirozzi and Xiaoxia Qin and Xuhui Bao and Paula K. Greer and Roger E McLendon and Hai Yan and Stephen T Keir and Darell D Bigner and Yiping He},
KMT2D (lysine (K)-specific methyltransferase 2D), formerly named MLL2 (myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone methyltransferase that plays an important role in regulating gene transcription. In particular, it targets histone H3 lysine 4 (H3K4), whose methylations serve as a gene activation mark. Recently, KMT2D has emerged as one of the most frequently mutated genes in a variety of cancers and in other human diseases, including lymphoma… CONTINUE READING


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