KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway

  title={KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway},
  author={Changlin Zhang and Chen-Long Song and Tianze Liu and Ranran Tang and Miao Chen and Fan Gao and Binyi Xiao and Ge Qin and Fen Shi and Wenbin Li and Yixin Li and Xiaoyan Fu and Dingbo Shi and Xiangsheng Xiao and Lan Kang and Wenlin Huang and Xiaojun Wu and Bing Tang and Wuguo Deng},
  journal={Cell Death \& Disease},
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells. KMT2A knockdown significantly inhibited cell viability and cell migration and induced apoptosis, whereas KMT2A overexpression effectively promoted cell proliferation in various melanoma cell lines. Further study showed that KMT2A regulated melanoma… 
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