KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.

@article{Yousef2000KLK12IA,
  title={KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.},
  author={George Makram Yousef and A Magklara and Eleftherios P Diamandis},
  journal={Genomics},
  year={2000},
  volume={69 3},
  pages={331-41}
}
Kallikreins are a subgroup of serine proteases that are involved in the posttranslational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. In rodents, kallikreins are encoded by a large multigene family, but in humans, only three genes have been identified. By using the positional candidate approach, we were able to identify a new kallikrein-like gene, tentatively named KLK12 (for kallikrein gene 12). This new gene maps to… CONTINUE READING