KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration

@article{Wang2017KLF7transfectedSC,
  title={KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration},
  author={Ying Wang and Wen-yuan Li and Hua Jia and Feng-Guo Zhai and Wenge Qu and Yong-Xia Cheng and Yan-cui Liu and Lingxiao Deng and Su-fen Guo and Zai-shun Jin},
  journal={Neuroscience},
  year={2017},
  volume={340},
  pages={319-332}
}
KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
TLDR
This study provides novel foundational data connecting the benefits of KLF7 in neural injury and repair to BMSC biology and function, and demonstrates a potential combination approach for the treatment of injured peripheral nerve via nerve graft transplant.
Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration
TLDR
Improved nerve conduction and sciatic function index score, and enhanced expression of neurofilaments, P0 (anti-peripheral myelin), and myelinated axon regeneration are revealed in a model of sciatic nerve gap.
Combinatory transplantation of mesenchymal stem cells with flavonoid small molecule in acellular nerve graft promotes sciatic nerve regeneration
TLDR
Novel foundational data is provided connecting the benefits of 7, 8-DHF treatment in neural injury and repair to BMSCs biology and function and demonstrates a potential combination approach for the treatment of injured peripheral nerve via nerve graft transplant.
Synergistic effects of G‐CSF and bone marrow stromal cells on nerve regeneration with acellular nerve xenografts
TLDR
G‐CSF administration and BMSCs transplantation synergistically promoted the regeneration of ANX‐bridged nerves, which offers a superior strategy to replace autografts in repairing peripheral nerve injuries.
Regeneration of sciatic nerves by transplanted microvesicles of human neural stem cells derived from embryonic stem cells
TLDR
The results indicated that the hESC-NSC-MVs group had the greatest ability to repair and reconstruct nerve structure and function and may have potential for applications in the field of nerve regenerative repair.
Combination of BMSCs‐laden acellular nerve xenografts transplantation and G‐CSF administration promotes sciatic nerve regeneration
TLDR
The union application of BMSCs‐implanted ANX and G‐CSF ameliorated the niche of neurotization and advanced nerve regeneration substantially and achieved the favorable effectiveness as an alternative to the autotransplantation.
AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury
TLDR
It is suggested that KLF7 promotes DPSN axonal plasticity and the formation of synapses with motor neurons at the caudal spinal cord, leading to improved functional recovery and further supporting the potential of AAV-KLF7 as a therapeutic agent for spinal cord injury.
Schwann Cells Enhance Penetration of Regenerated Axons into Three-Dimensional Microchannels
TLDR
It is demonstrated that migration of SCs promotes, significantly, the dorsal root ganglion (DRG) neurons to extend axons into three-dimensional channels and form aligned fascicular-like axon tracts, thereby demonstrating the beneficial effects of including SCs over NGF alone in enhancing axon penetration and myelination in three- dimensional microchannels.
Interaction between Schwann cells and other cells during repair of peripheral nerve injury
TLDR
A basic assessment of SC function post-PNI is provided, as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and, ultimately, repair of the injured nerve.
LncRNA BC083743 Promotes the Proliferation of Schwann Cells and Axon Regeneration Through miR-103-3p/BDNF After Sciatic Nerve Crush.
TLDR
In vivo experiments indicated that BC083743 overexpression promoted the repair of SNC and interacted with and regulated miR-103-3p, thereby promoting BDNF expression and SC proliferation and axon regeneration.
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