KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis.

@article{Li2011KLF4mediatedNR,
  title={KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis.},
  author={Dawei Li and Zhihai Peng and Huamei Tang and Ping Wei and Xiangyu Kong and Dongwang Yan and Fei Huang and Qiang Li and Xiangdong Le and Qi Li and Keping Xie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 11},
  pages={3558-68}
}
PURPOSE IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer. In this study, we sought to determine the clinical significance and underlying mechanisms of its dysregulated expression in human colon tumor specimens and murine models of this disease. EXPERIMENTAL DESIGN IFITM3 expression in a tissue microarray of tumor and matched normal colon tissue specimens and lymph node metastasis specimens obtained from 203 patients with colon cancer was measured… CONTINUE READING

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