KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1.

@article{Boon2007KLF2ST,
  title={KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1.},
  author={Reinier A Boon and Joost O. Fledderus and Oscar L. Volger and Eva J A van Wanrooij and Evangelia Pardali and Frank Weesie and J. J. W. Kuiper and H. Pannekoek and Peter Ten Dijke and Anton J. G. Horrevoets},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 3},
  pages={532-9}
}
OBJECTIVE The flow-responsive Kruppel-like factor 2 (KLF2) is crucial for maintaining endothelial cell quiescence. Here, we describe its detailed effects on transforming growth factor-beta (TGF-beta) signaling, which normally has proatherogenic effects on endothelium. METHODS AND RESULTS In-depth analysis of genome-wide expression data shows that prolonged lentiviral-mediated overexpression of KLF2 in human umbilical vein endothelial cells (HUVECs) diminishes the expression of a large panel… CONTINUE READING

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