KLF14 potentiates oxidative adaptation via modulating HO-1 signaling in castrate-resistant prostate cancer.

@article{Luo2019KLF14PO,
  title={KLF14 potentiates oxidative adaptation via modulating HO-1 signaling in castrate-resistant prostate cancer.},
  author={Xiaomei Luo and Jian-Zhou Liu and Bo-wen Wang and Qu Men and Y Ju and Feng-Yan Yin and Chao Zheng and Wei Li},
  journal={Endocrine-related cancer},
  year={2019},
  volume={26 1},
  pages={
          181-195
        }
}
Insights into the mechanisms by which key factors stimulate cell growth under androgen-depleted conditions is a premise to the development of effective treatments with clinically significant activity in patients with castration-resistant prostate cancer (CRPC). Herein, we report that, the expression of Krüppel-like factor 14 (KLF14), a master transcription factor in the regulation of lipid metabolism, was significantly induced in castration-insensitive PCa cells and tumor tissues from a mouse… 
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Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
TLDR
The redox signaling networks that augment AR signaling during PCa progression to CRPC, and the possible utility of Nrf2-activating agents as an adjunct to ADT are addressed.
JUND-dependent upregulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer.
TLDR
An indispensible role of JUND is highlighted, both as a target as a modifier of the oxidative stress signaling, in conferring an adaptive response during the pathogenesis of CDDP resistance in MIBC.
Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
TLDR
The generation and biological roles of ROS in PCa is discussed, new strategies based on the regulation of ROS for the treatment of PCa are provided and a subtle balance of intracellular ROS levels is required for cancer cell functions.
Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy
TLDR
The dual role of ROS in cancer and the self-adaptive ability of cancer cells should be taken into consideration for cancer prevention.
The role of KLF14 in multiple disease processes
TLDR
The functions of KLF14 are reviewed in physiologyical and pathological process, which include regulating cell signaling pathways, cell proliferation and differentiation, and tumorigenesis and immune regulation.
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel‐like factors in prostate cancer
TLDR
It is found that the KLFs and clinical feature‐based signatures may improve prognosis prediction in PCa and further promote patient stratification and disease management.
EZH2‐mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ
TLDR
Roles, mechanisms and implications of KLF14 in liver fibrosis are unknown and further studies are needed to establish a clear picture of its role in fibrosis.
Nuclear Localization of BRAFV600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells
TLDR
This study provides new information on the ability to selectively classify patients with cytosolic BRAF for selective BRAF inhibitors and offers an alternative treatment to patients with nuclear BRAFV600E and high HMOX1 expressions.
Transcription Factor KLF14 and Metabolic Syndrome
TLDR
Common attributes of its biochemical, physiological, and pathophysiological roles are described and the current challenges in understanding the role of KLF14 in metabolism are discussed and suggestions for future directions are provided.

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