KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway.


TGF-β plays a significant role in regulating pancreas islet function and maintaining their mass. KLF10, a TGF-β downstream gene, belongs to a group of Krüppel-like transcription factors that bind to the promoters of target genes and produce effects that mimic TGF-β as a tumor suppressor. Using ChIP-chip screening, SEI-1 was identified as a target gene that… (More)
DOI: 10.1016/j.biocel.2014.12.021

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