KLF family members regulate intrinsic axon regeneration ability.

  title={KLF family members regulate intrinsic axon regeneration ability.},
  author={Darcie L Moore and Murray G Blackmore and Ying Hu and Klaus H. Kaestner and John L. Bixby and Vance P. Lemmon and Jeffrey L. Goldberg},
  volume={326 5950},
Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon… CONTINUE READING
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