KLEIP deficiency in mice causes progressive corneal neovascular dystrophy.

  title={KLEIP deficiency in mice causes progressive corneal neovascular dystrophy.},
  author={Nicole Hahn and Christian T. Dietz and Sandra Kuehl and Urs Vossmerbaeumer and Jens Kroll},
  journal={Investigative ophthalmology & visual science},
  volume={53 6},
PURPOSE The BTB-kelch protein KLEIP/KLHL20 is an actin binding protein that regulates cell-cell contact formation and cell migration. The aim of our study was to characterize KLEIP's function in ocular health and disease in mice. METHODS KLEIP(-/-) mice were generated, and corneas were examined histologically and stained for keratin-1, loricrin, keratin-12, keratin-14, CD31, LYVE-1, F4/80, E-cadherin, and Ki67. Corneal abrasions were performed after eyelid opening. RESULTS Corneas of KLEIP… CONTINUE READING
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