KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

@article{Schumann2016KLBIA,
  title={KLB is associated with alcohol drinking, and its gene product $\beta$-Klotho is necessary for FGF21 regulation of alcohol preference},
  author={Gunter Schumann and Chunyu Liu and Paul F. O’Reilly and He Gao and Parkyong Song and Bing Xu and Barbara Ruggeri and Najaf Amin and Tianye Jia and Sarah R Preis and Marcelo Segura Lepe and Shizuo Akira and Caterina M Barbieri and Sebastian E. Baumeister and Stéphane Cauchi and Toni‐Kim Clarke and Stefan Enroth and Krista Fischer and Jenni H{\"a}llfors and Sarah E. Harris and Saskia Hieber and Edith Hofer and Jouke- Jan Hottenga and {\AA}sa Johansson and Peter K. Joshi and Niina E. Kaartinen and Jaana Laitinen and Rozenn N. Lemaitre and Anu Loukola and Jian’an Luan and Leo-Pekka Lyytik{\"a}inen and Massimo Mangino and Ani W. Manichaikul and Hamdi Mbarek and Yuri Milaneschi and Alireza Moayyeri and Kenneth J. Mukamal and Christopher P. Nelson and Jennifer A. Nettleton and Eemil Partinen and Rajesh Rawal and Antonietta Robino and Lynda M Rose and Cinzia Felicita Sala and Takashi Satoh and Reinhold Schmidt and Katharina E. Schraut and Robert A Scott and Albert Vernon Smith and John M. Starr and Alexander Teumer and Stella Trompet and Andr{\'e} G. Uitterlinden and Cristina Venturini and Anne-Claire Vergnaud and Niek Verweij and Veronique Vitart and Dragana Vuckovic and Juho Wedenoja and Loic Yengo and Bing Yu and Weihua Zhang and Jinghua Zhao and Dorret I. Boomsma and John C Chambers and Daniel I. Chasman and Toniolo Daniela and Eco J. C. de Geus and Ian J. Deary and Johan Gunnar Eriksson and T{\~o}nu Esko and Volker Eulenburg and Oscar H. Franco and Philippe Froguel and Christian Gieger and Hans J{\"o}rgen Grabe and Vilmundur G. Gudnason and Ulf Gyllensten and Tamara B. Harris and A-L. Hartikainen and Andrew C. Heath and Lynne J. Hocking and Albert Hofman and Cornelia Huth and Marjo-Riitta Jarvelin and Johan Wouter Jukema and Jaakko A. Kaprio and Jaspal S Kooner and Zolt{\'a}n Kutalik and Jari Lahti and Claudia Langenberg and Terho Lehtim{\"a}ki and Yongmei Liu and Pamela A. F. Madden and Nicholas Martin and Alanna C. Morrison and Brenda W.J.H. Penninx and Nicola Pirastu and Bruce M. Psaty and Olli T. Raitakari and Paul M. Ridker and Richard J. Rose and Jerome I. Rotter and Nilesh J. Samani and Helena Schmidt and Tim D. Spector and David J. Stott and David P. Strachan and Ioanna Tzoulaki and Pim van der Harst and Cornelia M. van Duijn and Pedro Marques‐Vidal and Peter Vollenweider and Nicholas J. Wareham and John B. Whitfield and James F. Wilson and Bruce H. R. Wolffenbuttel and Georgy Bakalkin and Evangelos Evangelou and Yun Liu and Kenneth M. Rice and Sylvane Desrivi{\`e}res and Steven A. Kliewer and David J. Mangelsdorf and Christian P. M{\"u}ller and Daniel Levy and Paul Elliott},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={14372 - 14377}
}
Excessive alcohol consumption is a major public health problem worldwide. [] Key Result We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.

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