KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

@article{Schumann2016KLBIA,
  title={KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference},
  author={G. Schumann and C. Liu and P. O’Reilly and H. Gao and Parkyong Song and B. Xu and B. Ruggeri and N. Amin and T. Jia and S. Preis and Marcelo Segura Lepe and S. Akira and C. Barbieri and S. Baumeister and S. Cauchi and T. Clarke and Stefan Enroth and K. Fischer and Jenni H{\"a}llfors and S. Harris and S. Hieber and E. Hofer and J. Hottenga and {\AA}. Johansson and P. Joshi and N. Kaartinen and J. Laitinen and R. Lemaitre and A. Loukola and J. Luan and L. Lyytik{\"a}inen and M. Mangino and A. Manichaikul and H. Mbarek and Y. Milaneschi and A. Moayyeri and K. Mukamal and C. Nelson and J. Nettleton and Eemil Partinen and R. Rawal and A. Robino and L. Rose and C. Sala and T. Satoh and R. Schmidt and K. Schraut and R. Scott and A. Smith and J. Starr and A. Teumer and S. Trompet and A. Uitterlinden and C. Venturini and A. Vergnaud and N. Verweij and V. Vitart and D. Vu{\vc}kovi{\'c} and J. Wedenoja and L. Yengo and B. Yu and W. Zhang and J. Zhao and D. Boomsma and J. Chambers and D. Chasman and Toniolo Daniela and E. D. de Geus and I. Deary and J. Eriksson and T. Esko and V. Eulenburg and O. Franco and P. Froguel and C. Gieger and H. Grabe and V. Gudnason and U. Gyllensten and T. Harris and A. Hartikainen and A. Heath and L. Hocking and A. Hofman and C. Huth and M. Jarvelin and J. Jukema and J. Kaprio and J. Kooner and Z. Kutalik and J. Lahti and C. Langenberg and T. Lehtim{\"a}ki and Y. Liu and P. Madden and N. Martin and A. Morrison and B. Penninx and N. Pirastu and B. Psaty and O. Raitakari and P. Ridker and R. Rose and J. Rotter and N. Samani and H. Schmidt and T. Spector and D. Stott and D. Strachan and I. Tzoulaki and P. van der Harst and C. V. van Duijn and P. Marques-Vidal and P. Vollenweider and N. Wareham and J. Whitfield and J. Wilson and B. Wolffenbuttel and G. Bakalkin and E. Evangelou and K. Rice and S. Desrivi{\`e}res and S. Kliewer and D. Mangelsdorf and C. M{\"u}ller and D. Levy and P. Elliott},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={14372 - 14377}
}
Excessive alcohol consumption is a major public health problem worldwide. [...] Key Result We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.Expand
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