KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

  title={KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.},
  author={Gunter Schumann and Chunyu Liu and Paul F. O'Reilly and He N Gao and Parkyong Song and Bing Xu and Barbara Ruggeri and Najaf Amin and Tianye Jia and Sarah Rosner Preis and Marcelo Segura Lepe and Shizuo Akira and Caterina M Barbieri and Sebastian E. Baumeister and St{\'e}phane Cauchi and Toni-Kim Clarke and Stefan Enroth and Krista Fischer and Jenni H{\"a}llfors and Sarah E Harris and Saskia Hieber and E Hofer and Jouke-Jan Hottenga and {\AA}sa Johansson and Peter K Joshi and Niina E. Kaartinen and Jaana Laitinen and Rozenn N Lemaitre and Anu Loukola and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Massimo Mangino and Ani Manichaikul and Hamdi Mbarek and Yuri Milaneschi and Alireza Moayyeri and Kenneth Jay Mukamal and Christopher P. Nelson and Jennifer A. Nettleton and Eemil Partinen and Rajesh Rawal and Antonietta Robino and L. Murray Rose and Cinzia Sala and Teturou Satoh and Reinhold Schmidt and Katharina Elfriede Schraut and Robert Scott and Albert Vernon Smith and John M. Starr and Alexander Teumer and Stella Trompet and Andr{\'e} G. Uitterlinden and Cristina Cantos Venturini and Anne Claire Vergnaud and Niek Verweij and Veronique Vitart and Dragana Vuckovic and Juho Wedenoja and Loic Yengo and Bing Yu and Wenwei Zhang and Jing Hua Zhao and Dorret I. Boomsma and John Campbell Chambers and Daniel Chasman and Toniolo Daniela and Eco J C de Geus and Ian J. Deary and Johan G Eriksson and T{\"o}nu Esko and Volker Eulenburg and O. H. Franco and Philippe Froguel and Christian Gieger and Hans J{\"o}rgen Grabe and Vilmundur Gudnason and Ulf Gyllensten and Tamara B. Harris and Anna Liisa Hartikainen and A Christopher Heath and Lynne J. Hocking and Albert Hofman and Cornelia Huth and Marjo-Riitta Jarvelin and J Wouter Jukema and Jaakko A Kaprio and Jaspal Singh Kooner and Zolt{\'a}n Kutalik and Jari Lahti and Claudia Langenberg and Terho Lehtim{\"a}ki and Yongmei Liu and Pamela A. F. Madden and Nicholas G. Martin and Alanna C. Morrison and Brenda W. J. H. Penninx and Nicola Pirastu and Bruce M. Psaty and Olli T. Raitakari and Paul M. Ridker and R. Reena Rose and Jerome I. Rotter and Nilesh J. Samani and Helena de Oliveira Schmidt and Tim D. Spector and David Stott and David P. Strachan and Ioanna Tzoulaki and Pim van der Harst and Cornelia M van Duijn and Pedro Marques-Vidal and Peter Vollenweider and Nicholas J Wareham and John B. Whitfield and James F Wilson and Bruce H. R. Wolffenbuttel and Georgy Bakalkin and Evangelos Evangelou and Yun Liu and Kenneth M Rice and Sylvane Desrivi{\`e}res and Steven Anthony Kliewer and David J Mangelsdorf and Christian P M{\"u}ller and Daniel A. Levy and Paul Elliott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 50},
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10-12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is… CONTINUE READING
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