KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats

@article{Li2017KK92AAN,
  title={KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats},
  author={Xia Li and Emmanuel Sturchler and Katarzyna Kaczanowska and Michael Cameron and Michelle Finn and Patrick Griffin and Patricia H. McDonald and A. Markou},
  journal={Psychopharmacology},
  year={2017},
  volume={234},
  pages={1633-1644}
}
RationaleGABAB receptors (GABABR) play a critical role in GABAergic neurotransmission in the brain and are thought to be one of the most promising targets for the treatment of drug addiction. GABABR positive allosteric modulators (PAMs) have shown promise as potential anti-addictive therapies, as they lack the sedative and muscle relaxant properties of full GABAB receptor agonists such as baclofen.ObjectivesThe present study was aimed at developing novel, selective, and potent GABABR PAMs with… CONTINUE READING
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