KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors.

@article{TaboneEglinger2008KITMI,
  title={KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors.},
  author={S{\'e}verine Tabone-Eglinger and Fr{\'e}d{\'e}ric Subra and Hiba El Sayadi and Laurent Alberti and Eric Tabone and J-M. Michot and Nathalie Th{\'e}ou-Anton and Antoinette Lemoine and J -Y Blay and Jean-François Emile},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 8},
  pages={
          2285-94
        }
}
PURPOSE Gastrointestinal stromal tumors (GIST) are frequently associated with gain-of-function mutations of KIT, which can be inhibited by imatinib both in vitro and in vivo. The survival of patients with GIST, following imatinib therapy, has been correlated with the nature of mutations but not with KIT expression. EXPERIMENTAL DESIGN Subcellular localization, activation, and trafficking of the mature and the immature forms of KIT were investigated in GIST samples and in NIH3T3 cells infected… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS, ESTIMATED 57% COVERAGE

63 Citations

0510'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

The role of KIT in themanagement of patients with gastrointestinal stromal tumors

  • HornickJL, CD Fletcher
  • Hum Pathol
  • 2007

A knockin mouse model of gastrointestinal stromal tumor harboring kit K 641 E

  • BP Rubin, CR Antonescu, Scott-BrowneJP
  • Cancer Res
  • 2005

Similar Papers

Loading similar papers…