KIR enrichment at the effector-target cell interface is more sensitive than signaling to the strength of ligand binding.

@article{Borszcz2003KIREA,
  title={KIR enrichment at the effector-target cell interface is more sensitive than signaling to the strength of ligand binding.},
  author={Peter D Borszcz and Mary Peterson and Leah J. Standeven and Sheryl E. Kirwan and Mina Sandusky and Andrew Shaw and Eric O Long and Deborah N. Burshtyn},
  journal={European journal of immunology},
  year={2003},
  volume={33 4},
  pages={1084-93}
}
Target cell lysis by natural killer cells is inhibited by killer cell immunoglobulin-like receptors (KIR) that bind major histocompatibility complex class I molecules. Many lymphocyte receptors, including KIR, become enriched at the interface with ligand-bearing cells. The contribution of the enrichment to inhibitory signaling has not been determined. We now describe a KIR variant with enhanced green fluorescent protein (EGFP) at the N terminus that can mediate inhibitory signaling, but its… CONTINUE READING

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