KIR and HLA-C Interactions Promote Differential Dendritic Cell Maturation and Is a Major Determinant of Graft Failure following Kidney Transplantation

@inproceedings{Hanvesakul2011KIRAH,
  title={KIR and HLA-C Interactions Promote Differential Dendritic Cell Maturation and Is a Major Determinant of Graft Failure following Kidney Transplantation},
  author={Raj Hanvesakul and Chandrashekhar A Kubal and J. Moore and Desley Neil and Mark Cook and Simon Ball and David Briggs and P. B. Moss and Paul Cockwell},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND HLA-C is an important ligand for killer immunoglobulin like receptors (KIR) that regulate natural killer (NK) cell function. Based on KIR specificity HLA-C molecules are allocated into two groups, HLA-C1 or HLA-C2; HLA-C2 is more inhibiting to NK cell function than HLA-C1. We studied the clinical importance of HLA-C genotypes on the long-term graft survival of 760 kidney transplants performed at our centre utilising a population based genetic study and cell culture model to define… CONTINUE READING
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