KIR-HLA footprints and NK cell-mediated recognition of HIV-1

Abstract

Background Increasing data suggest an important role of KIR+ NK cells in the control of HIV-1, however the precise mechanisms on how NK cells recognize HIV-1-infected cells remain poorly understood. KIRs can bind to HLA class I molecules, but the binding affinity of these interactions is dependent on the HLA class I presented epitope. Recent reports have… (More)
DOI: 10.1186/1742-4690-9-S2-P170

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