KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.

@article{Oevermann2014KIRBH,
  title={KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.},
  author={Lena Oevermann and Sebastian U. Michaelis and Markus Mezger and Peter A. Lang and Jacek Toporski and Alice Bertaina and Marco Zecca and Alessandro Moretta and Franco Locatelli and Rupert Handgretinger},
  journal={Blood},
  year={2014},
  volume={124 17},
  pages={2744-7}
}
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a… CONTINUE READING
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