KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons

@inproceedings{Hung2016KIF1AM,
  title={
KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons},
  author={Christy Oi Ying Hung and Michael P. Coleman},
  booktitle={Traffic},
  year={2016}
}
Neurons rely heavily on axonal transport to deliver materials from the sites of synthesis to the axon terminals over distances that can be many centimetres long. KIF1A is the neuron-specific kinesin with the fastest reported anterograde motor activity. Previous studies have shown that KIF1A transports a subset of synaptic proteins, neurofilaments and dense-core vesicles. Using two-colour live imaging, we showed that beta-secretase 1 (BACE1)-mCherry moves together with KIF1A-GFP in both the… CONTINUE READING
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