KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals

  title={KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals},
  author={Susana Moleirinho and Nan-Shan Chang and Andrew H Sims and Andrew M. Tilston-L{\"u}nel and Liselotte Angus and Ann Steele and Victor R. Boswell and Susan Carol Barnett and Christopher J Ormandy and Dana Faratian and Frank Gunn-Moore and Paul A Reynolds},
The Salvador/Warts/Hippo (Hippo) signaling pathway defines a novel signaling cascade regulating cell contact inhibition, organ size control, cell growth, proliferation, apoptosis and cancer development in mammals. The upstream regulation of this pathway has been less well defined than the core kinase cassette. KIBRA has been shown to function as an upstream member of the Hippo pathway by influencing the phosphorylation of LATS and YAP, but functional consequences of these biochemical changes… CONTINUE READING
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