KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.

  title={KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.},
  author={A. Shirai and J. Ikeda and S. Kawashima and T. Tamaoki and T. Kamiya},
  journal={Journal of dermatological science},
  volume={25 3},
  • A. Shirai, J. Ikeda, +2 authors T. Kamiya
  • Published 2001
  • Biology, Medicine
  • Journal of dermatological science
  • KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of whole skin pieces from 4-week-old mice which we earlier established, KF19418 promoted hair follicle elongation as in the case of minoxidil. After topical application for 2 weeks of KF19418 or minoxidil to dorsal skin of hair-clipped mouse alopecia model, KF19418 at 1% suspension accelerated hair… CONTINUE READING
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