KEEPS: The Kronos Early Estrogen Prevention Study.

  title={KEEPS: The Kronos Early Estrogen Prevention Study.},
  author={S. Mitchell Harman and Eliot A. Brinton and Marcelle I. Cedars and Roger Lobo and Joann E. Manson and George R. Merriam and Virginia M Miller and Frederick Naftolin and Nanette F. Santoro},
  journal={Climacteric : the journal of the International Menopause Society},
  volume={8 1},
Observational studies have indicated that hormone therapy given at or after menopause is linked to substantial reduction in cardiovascular disease and its risk factors. Recent findings from the Women's Health Initiative (WHI) clinical trial, however, indicate that combined estrogen plus progestin hormone therapy, as well as estrogen-alone hormone therapy (given to women without a uterus), is ineffective in preventing the new onset of cardiac events in previously healthy late menopausal women… CONTINUE READING