KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.

@article{Antonescu2009KDRAM,
  title={KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.},
  author={Cristina R Antonescu and Akihiko Yoshida and Tianhuo Guo and Ning-en Chang and Lei Zhang and Narasimhan P. Agaram and L Qin and Murray F. Brennan and Samuel Singer and Robert G Maki},
  journal={Cancer research},
  year={2009},
  volume={69 18},
  pages={7175-9}
}
Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct clinical settings, such as radiation or associated chronic lymphedema. Although representing only 1% to 2% of soft tissue sarcomas, vascular sarcomas provide unique insight into the general process of tumor angiogenesis. However, no molecular candidates have been identified to guide a specific therapeutic intervention. By expression profiling… CONTINUE READING